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The Impact of the Eye in Dementia: The Eye and its Role in Diagnosis and Follow‐up

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García Martín, Elena Salobrar and Ramírez Sebastián, Ana Isabel and Hoz Montañana, Rosa de and Rojas, Pilar and Salazar Corral, Juan José and Rojas López, Blanca and Yubero Pancorbo, Raquel and Gil, Pedro and Triviño Casado, Alberto and Ramirez Sebastian, Jose Manuel (2016) The Impact of the Eye in Dementia: The Eye and its Role in Diagnosis and Follow‐up. In Update on Dementia. Intech, pp. 379-426. ISBN 978-953-51-2655-3

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Official URL: http://dx.doi.org/10.5772/64490




Abstract

Over the last few decades, the importance of ophthalmic examination in neurodegenerative diseases of the CNS has reportedly increased. The retina is an extension of the CNS and thus should not be surprising to find abnormal results in both the test exploring visual processing and those examining the retina of patients with CNS degeneration. Current in vivo imaging techniques are allowing ophthalmologists to detect and quantify data consistent with the histopathological findings described in the retinas of Alzheimer’s disease (AD) patients and may help to reveal unsuspected retinal and optic‐nerve repercussions of other CNS diseases. In this chapter, we perform an analysis of the physiological changes in ocular and cerebral ageing. We analyse the ocular manifestations in CNS disorders such as stroke, AD and Parkinson’s disease. In addition, the pathophysiology of both the eye and the visual pathway in AD are described. The value of the visual psychophysical tests in AD diagnosis is reviewed as well as the main findings of the optical coherence tomography as a contribution to the diagnosis and monitoring of the disease. Finally, we examine the association of two neurodegenerative diseases, AD and glaucoma, as mere coincidence or possible role in the progression of the neurodegeneration.


Item Type:Book Section
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Open Access

Uncontrolled Keywords:Neurodegenerative disease ; Alzheimer ; Optical coherence tomography ; Contrast sensitivity test
Subjects:Medical sciences > Medicine > Diagnostic imaging and Nuclear medicine
Medical sciences > Medicine > Geriatrics
Medical sciences > Medicine > Neurosciences
Medical sciences > Medicine > Ophtalmology
ID Code:39570
Deposited On:26 Oct 2016 08:51
Last Modified:07 Nov 2016 18:43

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