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Antibiotic-resistant Klebsiella pneumoniae and Escherichia coli high-risk clones and an IncFII(k) mosaic plasmid hosting Tn1 (blaTEM-4) in isolates from 1990 to 2004

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Rodríguez, Irene and Novais, Ângela and Lira, Felipe and Valverde, Aránzazu and Curião, Tânia and Martínez, José Luis and Baquero, Fernando and Cantón, Rafael and Coque, Teresa M (2015) Antibiotic-resistant Klebsiella pneumoniae and Escherichia coli high-risk clones and an IncFII(k) mosaic plasmid hosting Tn1 (blaTEM-4) in isolates from 1990 to 2004. Antimicrobial agents and chemotherapy, 59 (5). pp. 2904-8. ISSN 1098-6596

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Official URL: http://aac.asm.org/content/59/5/2904



Abstract

We describe the genetic background of bla(TEM-4) and the complete sequence of pRYC11::bla(TEM-4), a mosaic plasmid that is highly similar to pKpQIL-like variants, predominant among TEM-4 producers in a Spanish hospital (1990 to 2004), which belong to Klebsiella pneumoniae and Escherichia coli high-risk clones responsible for the current spread of different antibiotic resistance genes. Predominant populations of plasmids and host adapted clonal lineages seem to have greatly contributed to the spread of resistance to extended-spectrum cephalosporins.


Item Type:Article
Subjects:Medical sciences > Veterinary
ID Code:39627
Deposited On:09 Jan 2017 16:31
Last Modified:09 Jan 2017 16:31

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