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Klebsiella pneumoniae sequence type 11 from companion animals bearing ArmA methyltransferase, DHA-1 β-lactamase, and QnrB4

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Hidalgo, Laura and Gutiérrez, Belén and Martínez Ovejero, Cristina and Carrilero Aguado, Laura and Matrat, Stephanie and Saba, Courage K S and Santos López, Alfonso and Thomas López, Daniel and Hoefer, Andreas and Suárez Rodríguez, Mónica and Santurde Sánchez, Gloria and Martín Espada, Carmen and González Zorn, Bruno (2013) Klebsiella pneumoniae sequence type 11 from companion animals bearing ArmA methyltransferase, DHA-1 β-lactamase, and QnrB4. Antimicrobial agents and chemotherapy, 57 (9). pp. 4532-4. ISSN 1098-6596

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Official URL: http://aac.asm.org/content/57/9/4532.full



Abstract

Seven Klebsiella pneumoniae isolates from dogs and cats in Spain were found to be highly resistant to aminoglycosides, and ArmA methyltransferase was responsible for this phenotype. All isolates were typed by multilocus sequence typing (MLST) as ST11, a human epidemic clone reported worldwide and associated with, among others, OXA-48 and NDM carbapenemases. In the seven strains, armA was borne by an IncR plasmid, pB1025, of 50 kb. The isolates were found to coproduce DHA-1 and SHV-11 β-lactamases, as well as the QnrB4 resistance determinant. This first report of the ArmA methyltransferase in pets illustrates their importance as a reservoir for human multidrug-resistant K. pneumoniae.


Item Type:Article
Subjects:Medical sciences > Veterinary
ID Code:39654
Deposited On:09 Jan 2017 16:42
Last Modified:09 Jan 2017 16:42

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