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SatR is a repressor of fluoroquinolone efflux pump SatAB

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Escudero, José Antonio and San Millán, Álvaro and Montero Serra, Natalia and Gutiérrez, Belén and Martínez Ovejero, Cristina and Carrilero Aguado, Laura and González Zorn, Bruno (2013) SatR is a repressor of fluoroquinolone efflux pump SatAB. Antimicrobial agents and chemotherapy, 57 (7). pp. 3430-3. ISSN 1098-6596

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Official URL: http://dx.doi.org/10.1128 /AAC.00515-13



Abstract

Streptococcus suis is an emerging zoonotic agent responsible for high-mortality outbreaks among the human population in China. In this species, the ABC transporter SatAB mediates fluoroquinolone resistance when overexpressed. Here, we describe and characterize satR, an open reading frame (ORF) encoding a MarR superfamily regulator that acts as a repressor of satAB. satR is cotranscribed with satAB, and its interruption entails the overexpression of the pump, leading to a clinically relevant increase in resistance to fluoroquinolones.


Item Type:Article
Subjects:Medical sciences > Veterinary
ID Code:39657
Deposited On:09 Jan 2017 16:46
Last Modified:09 Jan 2017 16:46

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