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Molecular organization of small plasmids bearing blaTEM-1 and conferring resistance to β-lactams in Haemophilus influenzae

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Søndergaard, Annette and San Millan, Alvaro and Santos López, Alfonso and Nielsen, Signe M and González Zorn, Bruno and Nørskov-Lauritsen, Niels (2012) Molecular organization of small plasmids bearing blaTEM-1 and conferring resistance to β-lactams in Haemophilus influenzae. Antimicrobial agents and chemotherapy, 56 (9). pp. 4958-60. ISSN 1098-6596

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Official URL: http://aac.asm.org/content/56/9/4958.full



Abstract

TEM-1 is the dominant β-lactamase of Haemophilus influenzae and can be located on small plasmids. Three distinct plasmids with sizes from 4,304 to 5,646 nucleotides (nt) were characterized: pA1606, pA1209, and pPN223. In addition to TEM-1 and a replication enzyme of the Rep 3 superfamily, pA1606 carries a Tn3 resolvase gene and pA1606 and pA1209 carry an open reading frame (ORF) similar to a plasmid recombination enzyme gene described in Gram-positive bacteria. The plasmids transformed strain Rd to the ampicillin-resistant phenotype.


Item Type:Article
Subjects:Medical sciences > Veterinary
ID Code:39668
Deposited On:09 Jan 2017 15:34
Last Modified:09 Jan 2017 15:34

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