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Macular Thickness as a Potential Biomarker of Mild Alzheimer's Disease

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García Martín, Elena Salobrar and Rojas López, Blanca and Ramírez Sebastián, Ana Isabel and Hoz Montañana, Rosa de and Salazar Corral, Juan José and Yubero Pancorbo, Raquel and Gil, Pedro and Triviño Casado, Alberto and Ramirez Sebastian, Jose Manuel (2014) Macular Thickness as a Potential Biomarker of Mild Alzheimer's Disease. Ophthalmology, 121 (5). pp. 1149-1151. ISSN 0161-6420

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Official URL: http://dx.doi.org/10.1016/j.ophtha.2013.12.023




Abstract

Although several postmortem findings in the retina of patients with Alzheimer's disease (AD) are available, new biomarkers for early diagnosis and follow-up of AD are still lacking. It has been postulated that the defects in the retinal nerve fiber layer (RNFL) may be the earliest sign of AD, even before damage to the hippocampal region that affects memory. This fact may reflect retinal neuronal-ganglion cell death and axonal loss in the optic nerve in addition to aging.


Item Type:Article
Uncontrolled Keywords:Macular thickness ; Biomarkers ; Alzheimer's disease
Subjects:Medical sciences > Medicine > Neurosciences
Medical sciences > Medicine > Ophtalmology
Medical sciences > Optics > Eyes anatomy
ID Code:39714
Deposited On:26 Oct 2016 08:01
Last Modified:07 Nov 2016 18:46

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