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Polymyxin resistance caused by mgrB inactivation is not associated with significant biological cost in Klebsiella pneumoniae

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Cannatelli, Antonio and Santos López, Alfonso and Giani, Tommaso and González Zorn, Bruno and Rossolini, Gian Maria (2015) Polymyxin resistance caused by mgrB inactivation is not associated with significant biological cost in Klebsiella pneumoniae. Antimicrobial agents and chemotherapy, 59 (5). pp. 2898-900. ISSN 1098-6596

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Official URL: http://aac.asm.org/content/59/5/2898.full



Abstract

The inactivation of the mgrB gene, which encodes a negative-feedback regulator of the PhoPQ signaling system, was recently shown to be a common mutational mechanism responsible for acquired polymyxin resistance among carbapenemase-producing Klebsiella pneumoniae strains from clinical sources. In this work, we show that mgrB mutants can easily be selected in vitro from different K. pneumoniae lineages, and mgrB inactivation is not associated with a significant biological cost.


Item Type:Article
Subjects:Medical sciences > Veterinary
ID Code:39730
Deposited On:09 Jan 2017 16:25
Last Modified:09 Jan 2017 16:25

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