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Diversity of LFPs Activated in Different Target Regions by a Common CA3 Input

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Martín Vazquez, Gonzalo and Benito, Nuria and Makarov, Valeri A. and Herreras, Oscar and Makarova, Julia (2016) Diversity of LFPs Activated in Different Target Regions by a Common CA3 Input. Cerebral Cortex, 26 (10). pp. 4082-4100. ISSN 10473211

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Official URL: http://cercor.oxfordjournals.org/content/early/2015/09/22/cercor.bhv211.abstract




Abstract

Identifying the pathways contributing to local field potential (LFP) events and oscillations is essential to determine whether synchronous interregional patterns indicate functional connectivity. Here, we studied experimentally and numerically how different target structures receiving input from a common population shape their LFPs. We focused on the bilateral CA3 that sends gamma-paced excitatory packages to the bilateral CA1, the lateral septum, and itself (recurrent input). The CA3-specific contribution was isolated from multisite LFPs in target regions using spatial discrimination techniques. We found strong modulation of LFPs by target-specific features, including the morphology and population arrangement of cells, the timing of CA3 inputs, volume conduction from nearby targets, and co-activated inhibition. Jointly they greatly affect the LFP amplitude, profile, and frequency characteristics. For instance, ipsilateral (Schaffer) LFPs occluded contralateral ones, and septal LFPs arise mostly from remote sources while local contribution from CA3 input was minor. In the CA3 itself, gamma waves have dual origin from local networks: in-phase excitatory and nearly antiphase inhibitory. Also, waves may have different duration and varying phase in different targets. These results indicate that to explore the cellular basis of LFPs and the functional connectivity between structures, besides identifying the origin population/s, target modifiers should be considered.


Item Type:Article
Uncontrolled Keywords:CA3; Gamma oscillations; LFP biophysics; Local field potentials; Neuron models
Subjects:Sciences > Mathematics
ID Code:39894
Deposited On:05 Nov 2016 16:53
Last Modified:12 Dec 2018 15:06

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