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Infralimbic cortex controls the activity of the hypothalamus-pituitary adrenal axis and the formation of aversive memory: effects of environmental enrichment

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Ronzoni, Giacomo and Antón, María and Mora Teruel, Francisco and Segovia Camargo, Gregorio and Del Arco González, Alberto (2016) Infralimbic cortex controls the activity of the hypothalamus-pituitary adrenal axis and the formation of aversive memory: effects of environmental enrichment. Behavioural Brain Research, 297 . pp. 338-344. ISSN 0166-4328

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Official URL: http://www.journals.elsevier.com/behavioural-brain-research




Abstract

The aim of the present study was to investigate the effects of the stimulation and inhibition of the ventral part of the medial prefrontal cortex (infralimbic cortex) on basal and stress-induced plasma levels of corticosterone and on the acquisition of aversive memory in animals maintained in control and environmental enrichment (EE) conditions. Intracortical microinjections of the GABAA antagonist picrotoxin and agonist muscimol were performed in male Wistar rats to stimulate and inhibit, respectively, the activity of the infralimbic cortex. Injections were performed 60 min before foot shock stress and training in the inhibitory avoidance task. Picrotoxin injections into the infralimbic cortex increased basal plasma levels of corticosterone. These increases were higher in EE rats which suggest that EE enhances the control exerted by infralimbic cortex over the hypothalamus-pituitary-adrenal (HPA) axis and corticosterone release. Muscimol injections into the infralimbic cortex reduced the stress-induced plasma levels of corticosterone and the retention latency 24 h after training in the inhibitory avoidance performance in control and EE animals, respectively. These results further suggest that the infralimbic cortex is required for the activation of the HPA axis during stress and for the acquisition of contextual aversive memories.


Item Type:Article
Uncontrolled Keywords:Prefrontal Cortex, Picrotoxin, Muscimol, Stress, Corticosterone, Emotional Memory
Subjects:Medical sciences > Biology > Neurosciences
ID Code:39964
Deposited On:08 Nov 2016 12:06
Last Modified:08 Nov 2016 12:10

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