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Recent developments on dry eye disease treatment compounds

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Colligris, Basilio and Alkozi, Hanan Awad and Pintor, Jesús (2014) Recent developments on dry eye disease treatment compounds. Saudi Journal of Ophthalmology, 28 (1). pp. 19-30. ISSN 1319-4534

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Official URL: http://dx.doi.org/10.1016/j.sjopt.2013.12.003




Abstract

Dry eye syndrome is a common tears and ocular surface multifactorial disease, described by changes in the ocular surface epithelia related to reduced tears quantity and ocular surface sensitivity, leading to inflammatory reaction. Managing the eye inflammation proved helpful to patients with dry eye disease and current treatment is based on the use of topically applied artificial tear products/lubricants, tear retention management, stimulation of tear secretion and using anti-inflammatory drugs. In this article we revise the corresponding literature and patents assembling the new treatment approaches of novel and future pharmaceutical compounds destined for the dry eye disease treatment. The most frequent categories of compounds presented are secretagogues and anti-inflammatory drugs. These compounds are the research outcome of novel therapeutic strategies designed to reduce key inflammatory pathways and restore healthy tear film.


Item Type:Article
Additional Information:

Open Access funded by King Saud University
Under a Creative Commons license
https://www.elsevier.com/journals/saudi-journal-of-ophthalmology/1319-4534/open-access-journal

Uncontrolled Keywords:Dry eye, Anti-inflammatory, Keratoconjunctivitis sicca, Keratitis sicca, Xerophthalmia, Mucin secretion, Tear secretion, NSAID
Subjects:Medical sciences > Medicine > Pharmacology
Medical sciences > Medicine > Ophtalmology
Medical sciences > Optics > Eyes anatomy
ID Code:40797
Deposited On:20 Jan 2017 11:35
Last Modified:20 Jan 2017 12:34

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