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Recent advances in mesoporous silica nanoparticles for antitumor therapy: our contribution

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Baeza García, Alejandro and Manzano García, Miguel and Colilla, Montserrat and Vallet Regí, María (2016) Recent advances in mesoporous silica nanoparticles for antitumor therapy: our contribution. Biomaterials Science, 4 (5). pp. 803-813. ISSN 2047-4830

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Abstract

Since 2001, when our research group proposed for the first time MCM-41 as a drug release system, the scientific community has demonstrated a growing interest in mesoporous silica nanoparticles (MSNs) for their revolutionary potential in nanomedicine. Among the diverse pathologies that can be treated with MSNs, cancer has received increasing attention. MSNs can be loaded with large amounts of therapeutic cargoes and once intravenously administrated preferentially accumulate in solid tumours via the enhanced permeation and retention (EPR) effect. Herein we report the recent developments achieved by our research group as a pioneer in this field, highlighting: the design of sophisticated MSNs as stimuli-responsive drug delivery systems to release the entrapped cargo upon exposure to a given stimulus while preventing the premature release of highly cytotoxic drugs before reaching the target; transporting non-toxic prodrugs and the enzyme responsible for its conversion into cytotoxic agents into the same MSNs; improving the selectivity and cellular uptake by cancer cells by active targeting of MSNs; increasing the penetration of MSNs within the tumour mass, which is one of the major challenges in the use of NPs to treat solid tumours.


Item Type:Article
Additional Information:

RESEARCHER ID M-3378-2014 (María Vallet Regí)
ORCID 0000-0002-6104-4889 (María Vallet Regí)
RESEARCHER ID M-3316-2014 (Alejandro Baeza García)
ORCID 0000-0002-8408-3389 (Alejandro Baeza García)
RESEARCHER ID K-3719-2014 (Miguel Manzano García)
RESEARCHER ID M-3378-2014 (Miguel Manzano García)
ORCID 0000-0001-6238-6111 (Miguel Manzano García)

Uncontrolled Keywords:Mesenchymal stem-cells, Targeted-delivery vehicle, Controlled drug-delivery, In-vivo, Biomedical applications, Different morphologies, Cancer-chemotherapy, Anticancer drug, Solid tumors, Release
Subjects:Sciences > Chemistry > Materials
Sciences > Chemistry > Chemistry, Inorganic
ID Code:40822
Deposited On:31 Jan 2017 10:03
Last Modified:31 Mar 2017 12:02

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