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Preventing bacterial adhesion on scaffolds for bone tissue engineering

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Sánchez Salcedo, Sandra and Colilla, Montserrat and Izquierdo-Barba, Isabel and Vallet Regí, María (2016) Preventing bacterial adhesion on scaffolds for bone tissue engineering. International Journal of Bioprinting, 2 (1). pp. 20-34. ISSN 2424-8002

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Abstract

Bone implant infection constitutes a major sanitary concern which is associated to high morbidity and health costs. This manuscript focused on overviewing the main research efforts committed up to date to develop innovative alternatives to conventional treatments, such as those with antibiotics. These strategies mainly rely on chemical modifi-cations of the surface of biomaterials, such as providing it of zwitterionic nature, and tailoring the nanostructure surface of metal implants. These surface modifications have successfully allowed inhibition of bacterial adhesion, which is the first step to implant infection, and preventing long-term biofilm formation compared to pristine materials. These strate-gies could be easily applied to provide three-dimensional (3D) scaffolds based on bioceramics and metals, of which its manufacture using rapid prototyping techniques was reviewed. This opens the gates for the design and development of advanced 3D scaffolds for bone tissue engineering to prevent bone implant infections.
Keywords: Antibacterial adhesion, biofilm formation, zwitterionic surfaces, nanostructured surfaces, rapid prototyping 3D scaffolds, bone tissue engineering.


Item Type:Article
Additional Information:

RESEARCHER ID M-3378-2014 (María Vallet Regí)
ORCID 0000-0002-6104-4889 (María Vallet Regí)
RESEARCHER ID N-4501-2014 (Sandra Sánchez Salcedo)
ORCID 0000-0002-1889-2057 (Sandra Sánchez Salcedo)

Uncontrolled Keywords:Antibacterial adhesion, Biofilm formation, Zwitterionic surfaces, Nanostructured surfaces, Rapid prototyping 3D scaffolds, Bone tissue engineering
Subjects:Sciences > Chemistry > Chemical engineering
Sciences > Chemistry > Materials
Sciences > Chemistry > Chemistry, Inorganic
ID Code:40830
Deposited On:31 Jan 2017 12:52
Last Modified:03 Feb 2017 12:25

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