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Self-Immolative Polymers as novel pH-responsive gate keepers for drug delivery



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Gisbert Garzarán, Miguel and Lozano Borregón, Daniel and Vallet Regí, María and Manzano García, Miguel (2016) Self-Immolative Polymers as novel pH-responsive gate keepers for drug delivery. RSC Advances . ISSN 2046-2069 (In Press)

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Official URL: http://www.rsc.org/


A novel pH-sensitive nanocarrier based on mesoporous silica nanoparticles with self-immolative polymers blocking the pore openings is presented. Triggered release by acid pH is demonstrated, together with their in vitro biocompatibility and effective cell internalisation, which makes this new material a promising candidate for future applications in cancer treatment.

Item Type:Article
Additional Information:

RESEARCHER ID M-3378-2014 (María Vallet Regí)
ORCID 0000-0002-6104-4889 (María Vallet Regí)

Uncontrolled Keywords:Biomaterials, Polymers
Palabras clave (otros idiomas):Materiales biomédicos, Polímeros
Subjects:Sciences > Chemistry > Materials
Sciences > Chemistry > Chemistry, Inorganic
ID Code:40875
Deposited On:26 Jan 2017 13:16
Last Modified:03 Feb 2017 12:20

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