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Immunolocalisation of P2Y receptors in the rat eye

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Pintor, Jesús y Sánchez Nogueiro, Jesús y Irazu, Marta y Mediero Muñoz, Aránzazu y Pelaez, Teresa y Peral Cerdá, Assumpta (2004) Immunolocalisation of P2Y receptors in the rat eye. Purinergic Signalling, 1 (1). pp. 831-90. ISSN 1573-9538

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URL Oficial: http://dx.doi.org/10.1007/s11302-004-5072-5




Resumen

Nucleotides present an important role in ocular physiology which has been demonstrated by recent works that indicate their involvement in many ocular processes. P2Y are important among P2 receptors since they can control tear production, corneal wound healing, aqueous humour dynamics and retinal physiology. Commercial antibodies have allowed us to investigate the distribution of P2Y receptors in the cornea, anterior and posterior chamber of the eye and retina. The P2Y1 receptor was present mainly in cornea, ciliary processes, and trabecular meshwork. The P2Y2 receptors were present in cornea, ciliary processes and retinal pigmented epithelium. P2Y4 was present in cornea, ciliary processes, photoreceptors, outer plexiform layer and ganglion cell layer. The P2Y6 presented almost an identical distribution as the P2Y4 receptor. The P2Y11 was also detectable in the retinal pigmented epithelium. The detailed distribution of the receptors clearly supports the recent findings indicating the relevant role of nucleotides in the ocular function.


Tipo de documento:Artículo
Información Adicional:

En Open Access en la web del editor.
Versión en abierto en PMC.
Received: 27 September 2004 ; Revised: 18 October 2004 ; Accepted: 18 October 2004

Palabras clave:Ciliary processes ; Cornea ; Eye ; Ocular surface ; P2 purinergic receptors ; Retina
Materias:Ciencias Biomédicas > Medicina > Bioquímica
Ciencias Biomédicas > Biología > Fisiología animal
Ciencias Biomédicas > Óptica y optometría > Anatomía ocular
Código ID:41036
Depositado:07 Feb 2017 08:17
Última Modificación:07 Feb 2017 08:17

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