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Dry Eye Treatment Based on Contact Lens Drug Delivery: A Review

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Guzmán Aránguez, Ana Isabel and Fonseca, Begoña and Carracedo Rodríguez, Juan Gonzalo and Martín Gil, Alba and Martínez Águila, Alejandro and Pintor, Jesús (2016) Dry Eye Treatment Based on Contact Lens Drug Delivery: A Review. Eye & contact lens: science & clinical practice, 42 (5). pp. 280-288. ISSN 1542-2321

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Official URL: http://dx.doi.org/10.1097/ICL.0000000000000184



Abstract

Dry eye disease affects a substantial segment of the word population with increasing frequency. It is a multifactorial disease of the ocular surface and tear film, which causes ocular discomfort, visual disturbances, and tear instability with potential damage to the cornea and conjunctiva. Because of its multifactorial etiology, the use of different pharmacological treatment for dry eye treatment has been proposed, which include anti-inflammatory molecules, lubricants or comfort agents, and secretagogues. However, in some cases these pharmacological approaches only relieve symptoms temporarily, and consequently, eye care professionals continue to have difficulties managing dry eye. To improve pharmacological therapy that allows a more efficient and long-term action, effective ocular drug delivery of the currently available drugs for dry eye treatment is required. Contact lenses are emerging as alternative ophthalmic drugs delivery systems that provide an increased residence time of the drug at the eye, thus leading to enhanced bioavailability and more convenient and efficacious therapy. In this article, we reviewed the different techniques used to prepare contact lens-based drug delivery systems and focused on articles that describe the delivery of compounds for dry eye treatment through contact lenses.


Item Type:Article
Additional Information:

Accepted July 19, 2015

Uncontrolled Keywords:Dry eye, Drug delivery, Ocular surface, Contact lenses
Subjects:Sciences > Chemistry > Biochemistry
Medical sciences > Medicine > Ophtalmology
Medical sciences > Optics > Contact lenses
ID Code:41247
Deposited On:13 Feb 2017 15:33
Last Modified:13 Feb 2017 15:33

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