Publication: Papel VEGF en la actividad vascular y en el tejido adiposo peritumoral en el carcinoma colorrectal
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2017-02-13
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Universidad Complutense de Madrid
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Abstract
Según datos de diciembre de 2014 en España el cáncer de colon es el tercero más frecuente en los hombres y el segundo en las mujeres. En términos generales, el cáncer colorrectal es el que tiene una mayor incidencia, un 15%. Un conocimiento de su fisiopatología, un diagnóstico precoz, una cirugía adecuada y un estadiaje correcto de cara al tratamiento adyuvante nos van a ayudar en el intento de mejorar su pronóstico. La angiogénesis tumoral sigue una serie de complejos pasos consecutivos que llevan a la formación de neovasos. El endotelio ha sido considerado como un complejo órgano sensorial. El VEGF es una proteína señalizadora implicada en la angiogénesis. Se ha demostrado que el VEGF estimula la división y la migración de células endoteliales. También es un vasodilatador e incrementa la permeabilidad vascular. La fosforilación reversible de proteínas juega un papel importante en la regulación de la actividad celular. La obesidad puede definirse como un exceso de peso a expensas del tejido adiposo. La obesidad es un factor de riesgo conocido para el desarrollo de CC. El tejido adiposo es un tejido acumulador de energía y un órgano endocrino que secreta moléculas multifuncionales que ejercen acciones proinflamatorias y pueden promover la iniciación y la progresión del tumor...
In Spain, as of December 2014, colorectal carcinoma (CC) was the third most frequent malignancy in men and the second most frequent in women. Generally speaking CC is the malignancy with the highest incidence of 15 %. Knowledge of its physiopathology, early diagnosis, well-executed surgical treatment, and correct staging oriented to adjuvant therapy, will have a role in improving its prognosis. Tumoral angiogenesis follows a complex staged pathway resulting in neo-vessel formation. Vascular endothelium has been considered a complex sensory organ. VEGF is a signalling protein involved in angiogenesis. It has been demonstrated that VEGF stimulates division and migration of endothelial cells; it has also a vasodilator effect and increases vascular permeability. Reversible protein phosphorilation plays an important role in cell activity regulation. Obesity can be defined as excessive weight due to excess adipose tissue. Obesity is a known risk factor for development of CC. Adipose tissue acts both as an energy-storage and an endocrine organ, secreting multifunctional macromolecules with pro-inflammatory activity, which can promote tumor initiation and development...
In Spain, as of December 2014, colorectal carcinoma (CC) was the third most frequent malignancy in men and the second most frequent in women. Generally speaking CC is the malignancy with the highest incidence of 15 %. Knowledge of its physiopathology, early diagnosis, well-executed surgical treatment, and correct staging oriented to adjuvant therapy, will have a role in improving its prognosis. Tumoral angiogenesis follows a complex staged pathway resulting in neo-vessel formation. Vascular endothelium has been considered a complex sensory organ. VEGF is a signalling protein involved in angiogenesis. It has been demonstrated that VEGF stimulates division and migration of endothelial cells; it has also a vasodilator effect and increases vascular permeability. Reversible protein phosphorilation plays an important role in cell activity regulation. Obesity can be defined as excessive weight due to excess adipose tissue. Obesity is a known risk factor for development of CC. Adipose tissue acts both as an energy-storage and an endocrine organ, secreting multifunctional macromolecules with pro-inflammatory activity, which can promote tumor initiation and development...
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Tesis inédita de la Universidad Complutense de Madrid, Facultad de Medicina, Departamento de Cirugía, leída el 08-02-2016