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Corneal Segmentation Analysis Increases Glaucoma Diagnostic Ability of Optic Nerve Head Examination, Heidelberg Retina Tomograph's Moorfield's Regression Analysis, and Glaucoma Probability Score

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Saenz Frances, Federico and Jañez Escalada, Luis and Berrozpe Villabona, Clara and Borrego Sanz, Lara and Morales Fernández, Laura and Acebal Montero, Alejandra and Méndez Hernández, Carmen D and Martínez de la Casa, Jose Maria and Santos Bueso, Enrique and García Sánchez, Julián and García Feijoo, Julián (2015) Corneal Segmentation Analysis Increases Glaucoma Diagnostic Ability of Optic Nerve Head Examination, Heidelberg Retina Tomograph's Moorfield's Regression Analysis, and Glaucoma Probability Score. Journal of Ophthalmology . ID 21595-8 p.. ISSN 2090-004X

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Official URL: http://dx.doi.org/10.1155/2015/215951




Abstract

Purpose. To study whether a corneal thickness segmentation model, consisting in a central circular zone of 1 mm radius centered at the corneal apex (zone I) and five concentric rings of 1 mm width (moving outwards: zones II to VI), could boost the diagnostic accuracy of Heidelberg Retina Tomograph's (HRT's) MRA and GPS. Material and Methods. Cross-sectional study. 121 healthy volunteers and 125 patients with primary open-angle glaucoma. Six binary multivariate logistic regression models were constructed (MOD-A1, MOD-A2, MOD-B1, MOD-B2, MOD-C1, and MOD-C2). The dependent variable was the presence of glaucoma. In MOD-A1, the predictor was the result (presence of glaucoma) of the analysis of the stereophotography of the optic nerve head (ONH). In MOD-B1 and MOD-C1, the predictor was the result of the MRA and GPS, respectively. In MOD-B2 and MOD-C2, the predictors were the same along with corneal variables: central, overall, and zones I to VI thicknesses. This scheme was reproduced for model MOD-A2 (stereophotography along with corneal variables). Models were compared using the area under the receiver operator characteristic curve (AUC). Results. MOD-A1-AUC: 0.771; MOD-A2-AUC: 0.88; MOD-B1-AUC: 0.736; MOD-B2-AUC: 0.845; MOD-C1-AUC: 0.712; MOD-C2-AUC: 0.838. Conclusion. Corneal thickness variables enhance ONH assessment and HRT's MRA and GPS diagnostic capacity.


Item Type:Article
Additional Information:

Received 1 March 2015; Accepted 5 May 2015

Uncontrolled Keywords:Glaucoma; Optic nerve; OCT; Retinal tomography; Corneal segmentation; Diagnosis
Subjects:Medical sciences > Medicine > Ophtalmology
Medical sciences > Optics > Imaging systems
ID Code:41292
Deposited On:17 Feb 2017 12:57
Last Modified:17 Feb 2017 12:57

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