Publication: Análisis del ritmo circadiano de la presión intraocular en pacientes hipertensos oculares y en sujetos normales
Loading...
Files
Official URL
Full text at PDC
Publication Date
2017-02-27
Authors
Advisors (or tutors)
Martínez de la Casa Fernández-Borrella, José Mª
Editors
Journal Title
Journal ISSN
Volume Title
Publisher
Universidad Complutense de Madrid
Citations
Exportar
Abstract
El conocimiento de la PIO es importante en el diagnóstico, prevención y tratamiento del glaucoma ya que es el único factor de riesgo de dicha enfermedad tratable hoy día. La PIO no tiene un valor estático sino que fluctúa a lo largo del día. No existen en la actualidad métodos fiables que nos permitan conocer de forma continuada estas variaciones. La realización de curvas de PIO durante 24 horas nos aporta una aproximación de estas fluctuaciones y nos permite manejar los pacientes de forma más adecuada que cuando disponemos sólo de valores aislados. OBJETIVOS 1. Determinar el valor de la PIO media en nuestro entorno en sujetos sanos y en HTO. 2. Estudiar el comportamiento de la PIO durante 24 horas en sujetos sanos “en su ambiente natural” y en sujetos HTO en el ámbito hospitalario. 3. Conocer la variación de la PIO que se produce en función de la postura (sentado y en decúbito) en los individuos sanos y en HTO, así como analizar las relaciones existentes entre ellas. 4. Construir una “curva fisiológica” para ojos normales y HTO con la PIO en la posición en la que está el individuo en condiciones normales a la hora de esa determinación y compararlas. 5. Estudiar si existen diferencias en la PIO entre un ojo y el adelfo en un mismo individuo tanto si es normal como si es HTO. 6. Analizar la variación de la PIO en función del sexo y de la edad de los sujetos normales y en los HTO. 7. Buscar la existencia de una correlación entre los valores de PIO obtenidos en consulta y la PIO máxima que alcanza el individuo a lo largo del día, tanto si es HTO como si es normal. 8. Establecer el porcentaje de picos de PIO que ocurren fuera de los horarios habituales de consulta en los ojos tanto HTO como normales. 9. Establecer el porcentaje de nadir que ocurren fuera de los horarios habituales de consulta en los ojos tanto HTO como normales. MATERIAL Y MÉTODOS Se realizó un estudio transversal en el que se determinó la PIO cada 4 horas durante 24 horas en sujetos normales y en pacientes HTO utilizando un tonómetro de Perkins. Las tomas se realizaron tanto en posición sentada como en posición tumbada. Los individuos normales fueron estudiados en su domicilio mientras que los HTO fueron hospitalizados...
IOP is an important variable to know in the diagnosis, prevention and treatment of glaucoma, since it is the only glaucoma risk factor treatable at present. Intraocular pressure is not static, but fluctuates over the course of a 24-hour cycle. A reliable method that provides clinicians with continuous data of these variations is, however, not available at present. Drafting IOP curves for a 24-hour period provides an approximation to these fluctuations, and allows for more adequate management of patients than when only isolated values are available. OBJECTIVES 1. Determine mean IOP values of both healthy subjects and patients with OHT within our environment. 2. Study IOP fluctuations throughout the day in healthy subjects within their “ habitual environment ” and in OHT patients within a hospital environment. 3. Understand how IOP fluctuates depending on posture (sitting and supine) in both healthy individuals and OHT patients, as well as analyze any difference between them. 4. Build a “ physiological IOP curve ” for normal and OHT eyes, in which IOP measurements are taken in the posture in which each individual would be under normal circumstances at the time set for each measurement, and to compare the results. 5. Study whether there exist any differences in the IOP of an individual’s right and left eye, of both healthy and OHT subjects. 6. Analyze IOP variation depending on sex and age in healthy and OHT subjects. 7. Search for any correlation that may exist between the IOP values obtained in the office hours and the maximum IOP registered for an individual, whether a healthy subject or an OHT patient, throughout the day. 8. Establish the percentage of peaks that occur out of normal office hours for both healthy and OHT eyes. 9. Establish the percentage of valleys that occur out of normal office hours for both healthy and OHT eyes. METHODS A transversal study was carried out, in which IOP was measured every 4 hours for 24 hours in both healthy subjects and OHT patients using a Perkins tonometer. Measurements were taken with the individual in the sitting and supine position. Normal individuals were studied at their homes, while OHT patients were hospitalized...
IOP is an important variable to know in the diagnosis, prevention and treatment of glaucoma, since it is the only glaucoma risk factor treatable at present. Intraocular pressure is not static, but fluctuates over the course of a 24-hour cycle. A reliable method that provides clinicians with continuous data of these variations is, however, not available at present. Drafting IOP curves for a 24-hour period provides an approximation to these fluctuations, and allows for more adequate management of patients than when only isolated values are available. OBJECTIVES 1. Determine mean IOP values of both healthy subjects and patients with OHT within our environment. 2. Study IOP fluctuations throughout the day in healthy subjects within their “ habitual environment ” and in OHT patients within a hospital environment. 3. Understand how IOP fluctuates depending on posture (sitting and supine) in both healthy individuals and OHT patients, as well as analyze any difference between them. 4. Build a “ physiological IOP curve ” for normal and OHT eyes, in which IOP measurements are taken in the posture in which each individual would be under normal circumstances at the time set for each measurement, and to compare the results. 5. Study whether there exist any differences in the IOP of an individual’s right and left eye, of both healthy and OHT subjects. 6. Analyze IOP variation depending on sex and age in healthy and OHT subjects. 7. Search for any correlation that may exist between the IOP values obtained in the office hours and the maximum IOP registered for an individual, whether a healthy subject or an OHT patient, throughout the day. 8. Establish the percentage of peaks that occur out of normal office hours for both healthy and OHT eyes. 9. Establish the percentage of valleys that occur out of normal office hours for both healthy and OHT eyes. METHODS A transversal study was carried out, in which IOP was measured every 4 hours for 24 hours in both healthy subjects and OHT patients using a Perkins tonometer. Measurements were taken with the individual in the sitting and supine position. Normal individuals were studied at their homes, while OHT patients were hospitalized...
Description
Tesis inédita de la Universidad Complutense de Madrid, Facultad de Medicina, Departamento de Oftalmología y Otorrinolaringología, leída el 08-02-2016