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Tuning mesoporous silica dissolution in physiological environments: a review

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Paris, J.L. and Colilla, Montserrat and Izquierdo-Barba, Isabel and Manzano García, Miguel and Vallet Regí, María (2017) Tuning mesoporous silica dissolution in physiological environments: a review. Journal of Materials Science . ISSN 0022-2461 (In Press)

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Abstract

Matrix degradation has a major impact on the release kinetics of drug delivery systems. Regarding ordered mesoporous silica materials for biomedical applications, their dissolution is an important parameter that should be taken into consideration. In this paper, we review the main factors that govern the mesoporous silica dissolution in physiological environments. We also provide the necessary knowledge to researchers in the area for tuning the dissolution rate of those matrices, so the degradation could be controlled and the material behaviour optimised.


Item Type:Article
Additional Information:

RESEARCHER ID K-3719-2014 (Miguel Manzano García)
ORCID 0000-0001-6238-6111 (Miguel Manzano García)
RESEARCHER ID M-3378-2014 (María Vallet Regí)
ORCID 0000-0002-6104-4889 (María Vallet Regí)

Uncontrolled Keywords:Silica dissolution; matrix degradation; drug delivery systems; mesoporous silica nanoparticles
Subjects:Medical sciences > Pharmacy > Inorganic chemistry
ID Code:41657
Deposited On:19 May 2017 10:57
Last Modified:23 Jan 2018 08:59

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