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Double sequential encrypted targeting sequence: A new concept for bone cancer treatment

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Villaverde Cantizano, Gonzalo and Nairi, Valentina and Baeza, Alejandro and Vallet Regí, María (2017) Double sequential encrypted targeting sequence: A new concept for bone cancer treatment. Chemistry: a european journal (23). pp. 1-7. ISSN 0947-6539 (In Press)

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Official URL: http://eu.wiley.com/WileyCDA/



Abstract

The selective transportation of therapeutic agents to tumoral cells is usually achieved by their conjugation with targeting moieties able to recognize these cells. Unfortunately, simple and static targeting systems usually show selectivity lacks. Herein, double sequential encrypted targeting system is proposed as stimuliresponsive targeting analogue for selectivity enhancement. The system is able to recognize diseased bone tissue in first place, and once there, a hidden secondary targeting group is activated by the presence of an enzyme overproduced in the malignant tissue (cathepsin K), triggering the recognition of diseased cells. Transporting the cell targeting agent in a hidden conformation which contains a high selective tissular primary targeting, could avoid not only its binding to similar cell receptors but also the apparition of the binding-site barrier effect, which can enhance the penetration of the therapeutic agent within the affected zone. This strategy could be applied not only to conjugate drugs but also to drug loaded nanocarriers in order to improve the efficiency for bone cancer treatments.


Item Type:Article
Uncontrolled Keywords:Stimuli-responsive targeting, Dual-targeting, Nanooncology, Encrypted peptide, Osteosarcoma
Subjects:Medical sciences > Medicine > Oncology
Medical sciences > Pharmacy > Inorganic chemistry
ID Code:41662
Deposited On:31 Mar 2017 12:00
Last Modified:29 Mar 2018 23:01

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