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Tailoring the Structure of Bioactive Glasses: From the Nanoscale to Macroporous Scaffolds

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Vallet Regí, María and Salinas Sánchez, Antonio J. and Arcos Navarrete, Daniel (2016) Tailoring the Structure of Bioactive Glasses: From the Nanoscale to Macroporous Scaffolds. International Journal of Applied Glass Science, 7 (2). pp. 195-205. ISSN 2041-1286

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Official URL: http://eu.wiley.com/WileyCDA/



Abstract

Bioactive glasses have played a very important role in the development of new materials for bone tissue regeneration. The development of new synthesis and manufacturing methods allows the preparation of bioactive glasses with new chemical compositions, nanoscaled features, customized morphologies, and pore architectures. The composition of glasses can be designed at the atomic-molecular level to ensure bioactivity and beneficial effects including capabilities for enhancing osteogenesis and vascularization or to exert bactericide action. Moreover, the glasses can be prepared as mesoporous bioactive glasses, exhibiting ordered arrangements of nanometric pores. Through the control of the microstructure, glasses can be prepared to achieve suitable interactions with living cells. Finally, the scaffolds obtained with bioactive glasses must display interconnected pores over 100 m to make possible bone cell ingrowths and angiogenesis. In this article, the advances in the field of bioactive glasses through the control of the chemical, nanometer scale, microstructural properties, and architectural features are presented and discussed. A detailed control of these four levels of matter organization will allow optimizing the biological response of bioactive glasses when used in bone tissue regeneration.


Item Type:Article
Additional Information:

RESEARCH ID M-3378-2014 (María Vallet Regí)
ORCID 0000-0002-6104-4889 (María Vallet Regí)
RESEARCH ID M-3316-2014 (Antonio Salinas Sánchez)
ORCID 0000-0002-8408-3389 (Antonio Salinas Sánchez)
ORCID 0000-0002-5367-7272 (Daniel Arcos Navarrete)
RESEARCHER ID L-6167-2014 (Daniel Arcos Navarrete)

Uncontrolled Keywords:Bioactive glasses, Bone tissue engineering, Composition, Mesostructure, Microstructure
Subjects:Sciences > Chemistry > Materials
Sciences > Chemistry > Chemistry, Inorganic
ID Code:41677
Deposited On:04 Apr 2017 09:00
Last Modified:04 Apr 2017 10:43

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