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Mesoporous silica nanoparticles grafted with a light-responsive protein shell for highly cytotoxic antitumoral therapy

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Martínez Carmona, Marina and Baeza, Alejandro and Rodriguez Milla, Miguel A. and García Castro, Javier and Vallet Regí, María (2015) Mesoporous silica nanoparticles grafted with a light-responsive protein shell for highly cytotoxic antitumoral therapy. Journal of Materials Chemistry B, 3 (28). pp. 5746-5752. ISSN 2050-750X

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Abstract

A novel phototriggered drug delivery nanocarrier, which exhibits very high tumor cytotoxicity against human tumoral cells, is presented. This device is based on mesoporous silica nanoparticles decorated with a biocompatible protein shell cleavable by light irradiation. The proteins that compose the protein shell (avidin, streptavidin and biotinylated transferrin) act as targeting and capping agents at the same time, avoiding the use of redundant systems. The light responsive behavior is provided by a biotinylated photocleavable cross-linker covalently grafted on the mesoporous surface, which suffers photocleavage by UV radiation (366 nm). Human tumoral cells incubated in the presence of a very low particle concentration enter into the apoptotic stage after a short irradiation time. Thus, the system described here could be applied to the treatment of exposed tumors that affect the skin, oesophagus, and stomach, among others, and are easily accessible for light irradiation.


Item Type:Article
Additional Information:

RESEARCHER ID M-3378-2014 (María Vallet Regí)
ORCID 0000-0002-6104-4889 (María Vallet Regí)
ORCID 0000-0002-9042-8865 (Alejandro Baeza)
RESEARCHER ID: K-8193-2014(Alejandro Baeza)

Uncontrolled Keywords:Drug-delivery system, Transferrin-receptor, Targeted delivery, Solid tumors, In-vivo, Cancer, Release, Cells, Streptavidin, Toxicity
Subjects:Sciences > Chemistry > Materials
Sciences > Chemistry > Chemistry, Inorganic
ID Code:41694
Deposited On:21 Apr 2017 11:50
Last Modified:24 Apr 2017 07:54

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