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Decidua-derived mesenchymal stem cells as carriers of mesoporous silica nanoparticles. In vitro and in vivo evaluation on mammary tumors

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Paris, Juan L. and Torre, Paz de la and Manzano, Miguel and Cabanas, Victoria M. and Flores, Ana I. and Vallet Regí, María (2016) Decidua-derived mesenchymal stem cells as carriers of mesoporous silica nanoparticles. In vitro and in vivo evaluation on mammary tumors. Acta Biomaterialia, 33 . pp. 275-282. ISSN 1742-7061

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Abstract

The potential use of human Decidua-derived mesenchymal stem cells (DMSCs) as a platform to carry mesoporous silica nanoparticles in cancer therapy has been investigated. Two types of nanoparticles were evaluated. The nanoparticles showed negligible toxicity to the cells, a fast uptake and a long retention inside them. Nanoparticle location in the cell was studied by colocalization with the lysosomes. Moreover, the in vitro and in vivo migration of DMSCs towards tumors was not modified by the evaluated nanoparticles. Finally, DMSCs transporting doxorubicin-loaded nanoparticles were capable of inducing cancer cell death in vitro.


Item Type:Article
Additional Information:

RESEARCHER ID M-3378-2014 (María Vallet Regí)
ORCID 0000-0002-6104-4889 (María Vallet Regí)
RESEARCHER ID K-3719-2014 (Miguel Manzano García)
ORCID 0000-0001-6238-6111 (Miguel Manzano García)
RESEARCHER ID G-8740-2015 (María Victoria Cabañas Criado)
ORCID 0000-0002-4753-5665 (María Victoria Cabañas Criado)

Uncontrolled Keywords:Nanoparticles; Mesoporous silica; Nanomedicine; Human decidua-derived mesenchymal stem cells
Subjects:Sciences > Chemistry > Materials
Sciences > Chemistry > Chemistry, Inorganic
ID Code:41725
Deposited On:18 May 2017 12:35
Last Modified:16 Mar 2018 00:01

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