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Polymer-Grafted Mesoporous Silica Nanoparticles as Ultrasound-Responsive Drug Carriers

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Paris, J.L. y Cabañas Criado, Maria Victoria y Manzano García, Miguel y Vallet Regí, María (2015) Polymer-Grafted Mesoporous Silica Nanoparticles as Ultrasound-Responsive Drug Carriers. ACS Nano, 9 (11). pp. 11023-11033. ISSN 1936-0851

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URL Oficial: http://pubs.acs.org/



Resumen

A new ultrasound-responsive system based on mesoporous silica nanoparticles was developed for biomedical applications, grafting a copolymer on their surface that acts as gatekeeper of the pores. The nanoparticles can be loaded with a cargo at low temperature (4 degrees C), taking advantage of the open conformation that the polymer presents under these conditions. Then, at 37 degrees C the copolymer collapses closing the pore entrances and allowing the nanoparticles to carry the drugs at physiological temperature without premature release, which is of great importance when dealing with cytotoxic drugs in cancer treatments. Upon ultrasound irradiation, the sensitive polymer changes its hydrophobicity and, therefore, its conformation toward coil-like opening the gates and releasing the cargo. These hybrid nanoparticles have been shown to be noncytotoxic and can be internalized into LNCaP cells retaining their ultrasound-responsive capability in the cytoplasm of the cells. Moreover, doxorubicin-loaded hybrid MSNs were incubated with LNCaP cells to show their capacity to induce cell death only when the nanoparticles had been exposed to ultrasound. This work demonstrates that our hybrid-MSNs can be triggered by remote stimuli, which is of capital importance for future applications in drug delivery and cancer therapy.


Tipo de documento:Artículo
Información Adicional:

RESEARCHER ID K-3719-2014 (Miguel Manzano García)
ORCID 0000-0001-6238-6111 (Miguel Manzano García)
RESEARCHER ID M-3378-2014 (María Vallet Regí)
ORCID 0000-0002-6104-4889 (María Vallet Regí)
RESEARCHER ID G-8740-2015 (María Victoria Cabañas Criado)
ORCID 0000-0002-4753-5665 (María Victoria Cabañas Criado)

Palabras clave:Mesoporous silica, Ultrasound, Stimuli-responsive, Drug delivery, Nanomedicine
Materias:Ciencias > Química > Materiales
Ciencias > Química > Química inorgánica
Código ID:41731
Depositado:22 May 2017 08:58
Última Modificación:22 May 2017 14:31

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