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The neuroprotective actions of oestradiol and oestrogen receptors

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Arévalo, María Ángeles and Azcoitia Elías, Iñigo and García Segura, Luis Miguel (2015) The neuroprotective actions of oestradiol and oestrogen receptors. Nature Reviews Neuroscience, 16 . pp. 17-29. ISSN 1471-003X

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Abstract

Hormones regulate homeostasis by communicating through the bloodstream to the body’s organs, including the brain. As homeostatic regulators of brain function, some hormones exert neuroprotective actions. This is the case for the ovarian hormone 17β‑oestradiol, which signals through oestrogen receptors (ERs) that are widely distributed in the male and female brain. Recent discoveries have shown that oestradiol is not only a reproductive hormone but also a brain-derived neuroprotective factor in males and females and that ERs coordinate multiple signalling mechanisms that protect the brain from neurodegenerative diseases, affective disorders and cognitive decline.


Item Type:Article
Uncontrolled Keywords:Biología Celular, Hormonas, 17β‑oestradiol, Citología
Subjects:Medical sciences > Biology > Cytology
ID Code:41772
Deposited On:13 Mar 2017 16:08
Last Modified:10 May 2017 08:04

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