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Presence and Release of ATP from the Retina in an Alzheimer's Disease Model

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Pérez de Lara, María Jesús and Pintor, Jesús (2015) Presence and Release of ATP from the Retina in an Alzheimer's Disease Model. Journal of Alzheimer's Disease, 43 (1). pp. 177-181. ISSN 1387-2877

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Official URL: http://dx.doi.org/10.3233/JAD-141005



Abstract

The aim of this study was to assess the changes of extracellular ATP levels during the progress of Alzheimer's disease by using a murine model of the disease. Retinal nucleotide release was measured from flattened whole-mounts stimulated with 59 mM KCl or non-stimulated maintained in Ringer solution. Mice exhibited an increase in retinal ATP release as long as the pathology progressed up to 14 months. This value decreased to normal values by 18 months of age. Changes occurred also when comparing to non-pathological mice. The increase in the presence of ATP levels may contribute, together with other factors, to the changes in the functionality of the retina and the concomitant death of retinal cells.


Item Type:Article
Uncontrolled Keywords:Alzheimer's disease, ATP, B6C3F1 mice, B6C3-Tg (AβPPswe, PSEN1dE9) mice
Subjects:Medical sciences > Medicine > Biochemistry
Medical sciences > Medicine > Neurosciences
Medical sciences > Medicine > Ophtalmology
ID Code:42266
Deposited On:26 Apr 2017 17:28
Last Modified:27 Apr 2017 11:25

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