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Cysteine dietary supplementation reverses the decrease in mitochondrial ROS production at complex I induced by methionine restriction

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Gómez, A. and Gómez Sánchez, José and López Torres, Mónica and Naudí, Alba and Mota Martorrell, N. and Pamplona, R. and Barja de Quiroga, Gustavo (2015) Cysteine dietary supplementation reverses the decrease in mitochondrial ROS production at complex I induced by methionine restriction. Journal of Bioenergetics and Biomembranes, 47 (3). pp. 199-208. ISSN 0145-479X, ESSN: 1573-6881

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Official URL: https://link.springer.com/article/10.1007/s10863-015-9608-x



Abstract

It has been described that dietary cysteine reverses many of the beneficial changes induced by methionine restriction in aging rodents. In this investigation male Wistar rats were subjected to diets low in methionine, supplemented with cysteine, or simultaneously low in methionine and supplemented with cysteine. The results obtained in liver showed that cysteine supplementation reverses the decrease in mitochondrial ROS generation induced by methionine restriction at complex I. Methionine restriction also decreased various markers of oxidative and non-oxidative stress on mitochondrial proteins which were not reversed by cysteine. Instead, cysteine supplementation also lowered protein damage in association with decreases in mTOR activation. The results of the present study add the decrease in mitochondrial ROS production to the various beneficial changes induced by methionine restriction that are reversed by cysteine dietary supplementation.


Item Type:Article
Uncontrolled Keywords:Cysteine; Radicals; Mitochondria; Restriction; Methionine
Subjects:Medical sciences > Biology > Biochemistry
Medical sciences > Biology > Animal physiology
ID Code:42511
Deposited On:04 May 2017 11:52
Last Modified:03 Jul 2020 09:12

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