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Immune function parameters as markers of biological age and predictors of longevity

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Martínez de Toda Cabeza, Irene and Maté, Ianire and Vida, Carmen and Cruces, Julia and Fuente del Rey, Mónica de la (2016) Immune function parameters as markers of biological age and predictors of longevity. Aging, 8 (11). pp. 3110-3119. ISSN 1945-4589

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Official URL: http://www.aging-us.com/



Abstract

Chronological age is not a good indicator of how each individual ages and thus how to maintain good health. Due to the long lifespan in humans and the consequent difficulty of carrying out longitudinal studies, finding valid biomarkers of the biological age has been a challenge both for research and clinical studies. The aim was to identify and validate several immune cell function parameters as markers of biological age. Adult, mature, elderly and long‐lived human volunteers were used. The chemotaxis, phagocytosis, natural killer activity and lymphoproliferation in neutrophils and lymphocytes of peripheral blood were analyzed. The same functions were measured in peritoneal immune cells from mice, at the corresponding ages (adult, mature, old and long lived) in a longitudinal study. The results showed that the evolution of these functions was similar in humans and mice, with a decrease in old subjects. However, the long‐lived individuals maintained values similar to those in adults. In addition, the values of these functions in adult prematurely aging mice were similar to those in chronologically old animals, and they died before their non‐prematurely aging mice counterparts. Thus, the parameters studied are good markers of the rate of aging, allowing the determination of biological age.


Item Type:Article
Uncontrolled Keywords:immune function, biological age, biomarker, aging, longevity
Subjects:Medical sciences > Biology
Medical sciences > Biology > Animal physiology
Medical sciences > Biology > Mammals
ID Code:42707
Deposited On:11 May 2017 16:53
Last Modified:22 Feb 2018 12:34

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