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Understanding inbreeding depression, purging, and genetic rescue

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Hedrick, P. W. and García-Dorado, Aurora (2016) Understanding inbreeding depression, purging, and genetic rescue. Trends in ecology and evolution, 31 (12). pp. 940-952. ISSN 0169-5347, ESSN: 1872-8383

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Official URL: http://www.cell.com/trends/ecology-evolution/fulltext/S0169-5347(16)30158-6



Abstract

Inbreeding depression, the reduction of fitness caused by inbreeding, is a nearly universal phenomenon that depends on past mutation, selection, and genetic drift. Recent estimates suggest that its impact on individual fitness is even greater than previously thought. Genomic information is contributing to its detection and can enlighten important aspects of its genetic architecture. In natural populations, purging and genetic rescue mitigate fitness decline during inbreeding periods, and might be critical to population survival, thus, both mechanisms should be considered when assessing extinction risks. However, deliberate purging and genetic rescue involve considerable risk in the short and medium term, so that neither appears to be a panacea against high inbreeding depression.


Item Type:Article
Uncontrolled Keywords:Genetic drift; Genetic rescue; Inbreeding; Mutation; Purging
Subjects:Medical sciences > Biology > Genetics
ID Code:42862
Deposited On:23 May 2017 10:50
Last Modified:10 Dec 2018 15:30

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