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Low expression of CD39 and CD73 genes in centenarians compared with octogenarians

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Crooke, Almudena and Martínez Henández, Juan and Martínez López, Joaquín and Cruz Jentoft, Alfonso and Huete Toral, Fernando and Pintor, Jesús (2017) Low expression of CD39 and CD73 genes in centenarians compared with octogenarians. Immunity & Ageing, 14 (11). 5 p.. ISSN 1742-4933

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Official URL: http://dx.doi.org/10.1186/s12979-017-0094-3




Abstract

Ageing involves a progressive decline of the body’s regulatory systems including immune system. Adenosine regulates immune function by interaction with its receptors, mainly adenosine A2A receptor, present on the surface of immune cells. Furthermore, cellular response to this nucleoside is highly dependent on its extracellular concentration that is regulated by ecto-enzymes such as CD39 and CD73. Therefore, the aim of this study was to investigate the effect of age on adenosine A2A receptor, CD39 and CD73 gene expression. Changes in mRNA were measured by quantitative PCR from peripheral blood of young, middle-aged and older adults as well as centenarians. Centenarians showed a prominent decrease of CD39 and CD73 mRNA in comparison with older adults. Regarding to adenosine A2A receptor, we detected two subgroups of centenarians with high and low level of transcript. Additionally, adenosine A2A receptor mRNA level of centenarians, did not correlate with their cognitive impairment. In summary, our pilot study suggests that unlike of adenosine A2A receptor, the level of CD39 as well as CD73 mRNA could be a hallmark of successful human ageing.


Item Type:Article
Additional Information:

Received: 15 March 2017; Accepted: 15 May 2017; Published: 19 May 2017

Uncontrolled Keywords:Ageing; Centenarian; Adenosine receptor; Ecto-nucleotidase
Subjects:Sciences > Chemistry > Biochemistry
Medical sciences > Medicine > Geriatrics
ID Code:42876
Deposited On:29 May 2017 08:50
Last Modified:06 Jun 2017 07:43

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