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Vectorization of ultrasound-responsive nanoparticles in placental mesenchymal stem cells for cancer therapy

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Paris, J.L. and Torre, Paz de la and Cabañas Criado, Victoria and Manzano García, Miguel and Grau, Montserrat and Flores, Ana I. and Vallet Regí, María (2017) Vectorization of ultrasound-responsive nanoparticles in placental mesenchymal stem cells for cancer therapy. Nanoscale, 9 (17). pp. 5528-5537. ISSN 2040-3364

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Abstract

A new platform constituted by engineered responsive nanoparticles transported by human mesenchymal stem cells is here presented as a proof of concept. Ultrasound-responsive mesoporous silica nanoparticles are coated with polyethylenimine to favor their effective uptake by decidua-derived mesenchymal stem cells. The responsive-release ability of the designed nanoparticles is confirmed, both in vial and in vivo. In addition, this capability is maintained inside the cells used as carriers. The migration capacity of the nanoparticle-cell platform towards mammary tumors is assessed in vitro. The efficacy of this platform for anticancer therapy is shown against mammary tumor cells by inducing the release of doxorubicin only when the cell vehicles are exposed to ultrasound.


Item Type:Article
Subjects:Medical sciences > Medicine > Oncology
Medical sciences > Pharmacy > Inorganic chemistry
ID Code:42951
Deposited On:30 May 2017 10:00
Last Modified:08 May 2018 23:01

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