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Absence of SUN1 and SUN2 proteins in Arabidopsis thaliana leads to a delay in meiotic progression and defects in synapsis and recombination

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Varas, Javier and Graumann, K. and Osman, Kim and Pradillo Orellana, Mónica and Evans, David E. and Santos Coloma, Juan Luis and Armstrong, Susan J. (2015) Absence of SUN1 and SUN2 proteins in Arabidopsis thaliana leads to a delay in meiotic progression and defects in synapsis and recombination. The Plant Journal, 81 (2). pp. 329-346. ISSN 1365-313X

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Official URL: http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1365-313X/issues



Abstract

The movement of chromosomes during meiosis involves the location of their telomeres at the inner surface of the nuclear envelope (NE). Sad1/UNC-84 (SUN)-domain proteins are inner NE proteins that are part of complexes linking cytoskeletal elements with the nucleo skeleton, connecting telomeres to the force-generating mechanism in the cytoplasm. These proteins play a conserved role in chromosome dynamics in eukaryotes. Homologues of SUN-domain proteins have been identified in several plant species. In Arabidopsis thaliana two proteins which interact with each other, named AtSUN1 and AtSUN2, have been identified. Immuno localisation with antibodies to AtSUN1 and AtSUN2 proteins revealed that they were associated with the nuclear envelope during meiotic prophase I. Analysis of the double mutant Atsun1-1 Atsun2-2 has revealed severe meiotic defects, namely, a delay in the progression of meiosis, an absence of full synapsis, unresolved interlock-like structures and a reduction in the mean cell chiasma frequency. We propose that in Arabidopsis thaliana, overlapping functions of SUN1 and SUN2 ensure normal meiotic recombination and synapsis.


Item Type:Article
Uncontrolled Keywords:Arabidopsis thaliana, Saccharomyces cerevisiae, Schizosaccharomyces pombe, Caenorhabditis elegans, meiosis, nuclear envelope, SUN proteins
Subjects:Medical sciences > Biology
Medical sciences > Biology > Botany
Medical sciences > Biology > Genetics
ID Code:43056
Deposited On:31 May 2017 14:42
Last Modified:10 Dec 2018 15:30

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