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Barrier or carrier? Pulmonary surfactant and drug delivery

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Hidalgo Román, Alberto and Cruz Rodríguez, Antonio and Pérez Gil, Jesús (2015) Barrier or carrier? Pulmonary surfactant and drug delivery. European Journal of Pharmaceutics and Biopharmaceutics, 95 (A) . pp. 117-127. ISSN 0939-6411

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Official URL: https://www.journals.elsevier.com/european-journal-of-pharmaceutics-and-biopharmaceutics/



Abstract

To consider the lung as a target for drug delivery and to optimise strategies directed at the pulmonary route, it is essential to consider the role of pulmonary surfactant, a thin lipid–protein film lining the respiratory surface of mammalian lungs. Membrane-based surfactant multilayers are essential for reducing the surface tension at the respiratory air–liquid interface to minimise the work of breathing. Different components of surfactant are also responsible for facilitating the removal of potentially pathological entities such as microorganisms, allergens or environmental pollutants and particles. Upon inhalation, drugs or nanoparticles first contact the surfactant layer, and these interactions critically affect their lifetime and fate in the airways. This review summarises the current knowledge on the possible role and effects of the pulmonary surfactant system in drug delivery strategies. It also summarises the evidence that suggests that pulmonary surfactant is far from being an insuperable barrier and could be used as an efficient shuttle for delivering hydrophobic and hydrophilic compounds deep into the lung and the organism.


Item Type:Article
Uncontrolled Keywords:Air–liquid interface; Monolayer; Lung surfactant; Nanoparticles Inhalation Respiratory nanomedicine Nanocarriers
Subjects:Medical sciences > Biology
Medical sciences > Biology > Molecular biology
ID Code:43182
Deposited On:07 Jun 2017 14:42
Last Modified:31 Aug 2017 11:14

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