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Neuroprotective role of sphingosine-1-phosphate in L-BMAA treated neuroblastoma cells (SH-SY5Y)

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Muñoz Sáez, Emma and Munck García, Estefanía de and Arahuetes Portero, Rosa María and Vicente, Francisca and Ortiz López, Francisco Javier and Cantizani, Juan and Gómez Miguel, Begoña (2015) Neuroprotective role of sphingosine-1-phosphate in L-BMAA treated neuroblastoma cells (SH-SY5Y). Neuroscience Letters, 593 . pp. 83-89. ISSN 0304-3940

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Official URL: https://www.journals.elsevier.com/neuroscience-letters/



Abstract

Sphingosine-1-phosphate (S1P) is a bioactive lipid which regulates proliferation, cell migration, survival and differentiation by specific receptors activation. We studied its effects on L-BMAA treated neuroblastoma cells (SH-SY5Y), an amino acid that can trigger neurodegenerative diseases such as amyotrophic lateral sclerosis/Parkinson dementia complex (ALS/PDC). We found that S1P protects from necrosis and prevents the GSK3 increasing as long as the PI3K/AKT pathway is active. Moreover, GSK3 inhibition protects against neuronal death caused by L-BMAA.


Item Type:Article
Uncontrolled Keywords:SH-SY5Y; Sphingosine-1-phosphate; β-N-methylamine-l-alanine; Neuroprotection; GSK3
Subjects:Medical sciences > Biology
Medical sciences > Biology > Molecular biology
ID Code:43232
Deposited On:09 Jun 2017 17:33
Last Modified:12 Jun 2017 08:41

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