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Microwave-driven synthesis of bisphosphonate nanoparticles allows in vivo visualisation of atherosclerotic plaque

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Pellico, J. and Lechuga Vieco, A. V, and Benito, M. and García Segura, Juan Manuel and Fúster, V. and Ruiz Cabello, J. and Herranz, F. (2015) Microwave-driven synthesis of bisphosphonate nanoparticles allows in vivo visualisation of atherosclerotic plaque. RSC Advances, 3 . pp. 1661-1665. ISSN 2046-2069

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Abstract

A fast and reproducible microwave-driven process has allowed us to synthesise neridronate-functionalised nanoparticles. Contrary to tradition, the phosphate groups decorate the outside layer of the particles providing Ca2+ binding properties in vitro and selective accumulation in vivo in the atheroma plaque. In vivo and ex vivo detection by T2-weighted MRI is demonstrated and validated by histology. The accumulation in the plaque takes place in less than one hour following the intravenous injection, which is particularly suitable for clinical applications.


Item Type:Article
Uncontrolled Keywords:Bisphosphonate nanoparticles; atherosclerotic plaque
Subjects:Medical sciences > Biology
Medical sciences > Biology > Molecular biology
ID Code:43434
Deposited On:19 Jun 2017 16:16
Last Modified:20 Jun 2017 07:23

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