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The role and therapeutic potential of melatonin in age-related ocular diseases

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Crooke, Almudena and Huete Toral, Fernando and Colligris, Basilio and Pintor, Jesús (2017) The role and therapeutic potential of melatonin in age-related ocular diseases. Journal of Pineal Research . ISSN 1600-079X (In Press)

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Official URL: http://dx.doi.org/10.1111/jpi.12430




Abstract

The eye is continuously exposed to solar UV radiation and pollutants, making it prone to oxidative attacks. In fact, oxidative damage is a major cause of age-related ocular diseases including cataract, glaucoma, age-related macular degeneration and diabetic retinopathy. Since the nature of lens cells, trabecular meshwork cells, retinal ganglion cells, retinal pigment epithelial cells and photoreceptors is post-mitotic, autophagy plays a critical role in their cellular homeostasis. In age-related ocular diseases, this process is impaired, thus, oxidative damage becomes irreversible. Other conditions such as low- grade chronic inflammation and angiogenesis also contribute to the development of retinal diseases (glaucoma, age-related macular degeneration and diabetic retinopathy). As melatonin is known to have remarkable qualities such as antioxidant/antinitridergic, mitochondrial protector, autophagy modulator, anti-inflammatory and anti-angiogenic, it can represent a powerful tool to counteract all these diseases. The present review analyzes the role and therapeutic potential of melatonin in age-related ocular diseases, focusing on nitro-oxidative stress, autophagy, inflammation and angiogenesis mechanisms.


Item Type:Article
Additional Information:

Accepted manuscript online: 28 June 2017

Uncontrolled Keywords:Melatonin; Aging; Aged-related ocular diseases; Cataract; Glaucoma, Age-related macular degeneration; Diabetic retinopathy.
Subjects:Medical sciences > Medicine > Biochemistry
Medical sciences > Medicine > Ophtalmology
ID Code:43761
Deposited On:05 Jul 2017 10:06
Last Modified:28 Jun 2018 23:01

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