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A method for predicting protein structure from sequence

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Skolnick, Jeffrey and Kolinski, Andrzej and Brooks, Charles L. and Godzik, Adam and Rey, Antonio (1993) A method for predicting protein structure from sequence. Current Biology, 3 (7). pp. 414-423. ISSN 0960-9822

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Official URL: http://www.cell.com/current-biology/fulltext/0960-9822(93)90348-R



Abstract

The ability to predict the native conformation of a globular protein from its amino-acid sequence is an important unsolved problem of molecular biology. We have previously reported a method in which reduced representations of proteins are folded on a lattice by Monte Carlo simulation, using statistically-derived potentials. When applied to sequences designed to fold into four-helix bundles, this method generated predicted conformations closely resembling the real ones.


Item Type:Article
Subjects:Sciences > Chemistry > Chemistry, Physical and theoretical
ID Code:43831
Deposited On:18 Jul 2017 09:06
Last Modified:18 Jul 2017 09:06

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