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A method for predicting protein structure from sequence

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Skolnick, Jeffrey y Kolinski, Andrzej y Brooks, Charles L. y Godzik, Adam y Rey, Antonio (1993) A method for predicting protein structure from sequence. Current Biology, 3 (7). pp. 414-423. ISSN 0960-9822

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URL Oficial: http://www.cell.com/current-biology/fulltext/0960-9822(93)90348-R



Resumen

The ability to predict the native conformation of a globular protein from its amino-acid sequence is an important unsolved problem of molecular biology. We have previously reported a method in which reduced representations of proteins are folded on a lattice by Monte Carlo simulation, using statistically-derived potentials. When applied to sequences designed to fold into four-helix bundles, this method generated predicted conformations closely resembling the real ones.


Tipo de documento:Artículo
Materias:Ciencias > Química > Química física
Código ID:43831
Depositado:18 Jul 2017 09:06
Última Modificación:18 Jul 2017 09:06

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