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A mesoscopic stochastic model for the specific consumption rate in substrate-limited microbial growth



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Arranz, F. J. and Martínez Peinado, José (2017) A mesoscopic stochastic model for the specific consumption rate in substrate-limited microbial growth. PLoS ONE, 12 (2). ISSN 1932-6203

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Official URL: http://journals.plos.org/plosone/


The specific consumption rate of substrate, as well as the associated specific growth rate, is an essential parameter in the mathematical description of substrate-limited microbial growth. In this paper we develop a completely new kinetic model of substrate transport, based on recent knowledge on the structural biology of transport proteins, which correctly describes very accurate experimental results at near-zero substrate concentration values found in the literature, where the widespread Michaelis-Menten model fails. Additionally, our model converges asymptotically to Michaelis-Menten predictions as substrate concentration increases. Instead of the single active site enzymatic reaction of Michaelis-Menten type, the proposed model assumes a multi-site kinetics, simplified as an apparent all-or-none mechanism for the transport, which is controlled by means of the local substrate concentration in the close vicinity of the transport protein. Besides, the model also assumes that this local concentration is not equal to the mean substrate concentration experimentally determined in the culture medium. Instead, we propose that it fluctuates with a mostly exponential distribution of Weibull type.

Item Type:Article
Uncontrolled Keywords:mesoscopic stochastic; microbial growth
Subjects:Medical sciences > Biology
Medical sciences > Biology > Microbiology
ID Code:44087
Deposited On:26 Jul 2017 09:33
Last Modified:10 Dec 2018 15:30

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