Publication: Evolución del modelo de financiación de la investigación clínica en cáncer de mama durante las dos últimas décadas
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2017-08-23
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Universidad Complutense de Madrid
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Abstract
En las últimas décadas el ámbito sanitario está presentando una rápida evolución, con un incremento de conocimientos aplicables a la investigación que conllevan notables mejorías de la práctica clínica. Pero, ¿quién tiene los conocimientos para realizar una investigación con adecuado rigor científico? ¿Qué nos capacita para investigar: contar con los medios o con los conocimientos necesarios? ¿Cuáles son los objetivos de la investigación, académicos o monetarios? Con este proyecto se pretende evaluar la evolución cronológica de los estudios aleatorizados con medicamentos y el cambio evolutivo en sus promotores durante las dos últimas décadas (1990-2010) en la investigación clínica del cáncer de mama a nivel internacional, considerando las fuentes de financiación de los estudios indexados en PUBMED en este periodo de tiempo, comparando a su vez estadio de la enfermedad en el que se desarrolla, grupo farmacológico evaluado en dichos proyectos de investigación, tamaño muestral o fase de desarrollo en la que se lleva a cabo según los autores. HIPÓTESIS Y OBJETIVOS: - HIPÓTESIS: El patrocinio y promoción de la investigación en cáncer de mama ha presentado un cambio durante las 2 últimas décadas, disminuyendo la participación de Grupos Cooperativos y financiación pública en el desarrollo de ensayos clínicos en el momento actual, incrementándose la financiación privada...
In recent decades the health sector has been suffering a rapid evolution, with increased knowledge applicable to research involving significant improvements in clinical practice. But who has the expertise to conduct research with adequate scientific rigor? What enables us to investigate: having the means or the knowledge necessary? Which are the objectives of the research, academic or money reasons? This project aims to evaluate the chronological evolution of randomized trials with drugs and evolutionary change in their promoters during the last two decades (1990-2010) in clinical researches in breast cancer, considering the sources of funding studies indexed in PubMed in this period of time, comparing to turn stage of disease in which the pharmacological group evaluated in such research projects, sample size or stage of development in which it is carried out and it is developed according authors . HYPOTHESIS AND OBJECTIVES: - HYPOTHESIS: The sponsorship and promotion of the research in breast cancer has filed a change during the past 2 decades, reducing the involvement of Cooperative Groups and the development of clinical trials in the present, increasing the private funding. - MAIN OBJECTIVE: analyze the chronological evolution of sponsorship for clinical research in breast cancer, evaluating randomized indexed publications in PubMed from the last two decades. - SECONDARY OBJECTIVES: Evaluation of the correlation between funding and the status of the disease in which the drug is evaluated in the research. Study the correlation between the type of funding and the studied drug. Correlation between funding and phase of the study according to the authors...
In recent decades the health sector has been suffering a rapid evolution, with increased knowledge applicable to research involving significant improvements in clinical practice. But who has the expertise to conduct research with adequate scientific rigor? What enables us to investigate: having the means or the knowledge necessary? Which are the objectives of the research, academic or money reasons? This project aims to evaluate the chronological evolution of randomized trials with drugs and evolutionary change in their promoters during the last two decades (1990-2010) in clinical researches in breast cancer, considering the sources of funding studies indexed in PubMed in this period of time, comparing to turn stage of disease in which the pharmacological group evaluated in such research projects, sample size or stage of development in which it is carried out and it is developed according authors . HYPOTHESIS AND OBJECTIVES: - HYPOTHESIS: The sponsorship and promotion of the research in breast cancer has filed a change during the past 2 decades, reducing the involvement of Cooperative Groups and the development of clinical trials in the present, increasing the private funding. - MAIN OBJECTIVE: analyze the chronological evolution of sponsorship for clinical research in breast cancer, evaluating randomized indexed publications in PubMed from the last two decades. - SECONDARY OBJECTIVES: Evaluation of the correlation between funding and the status of the disease in which the drug is evaluated in the research. Study the correlation between the type of funding and the studied drug. Correlation between funding and phase of the study according to the authors...
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Tesis inédita de la Universidad Complutense de Madrid, Facultad de Medicina, Departamento de Medicina I, leída el 01-02-2016