Publication: Valor pronóstico del volumen de sangrado intracerebral tras rotura de aneurisma cerebral
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Publication Date
2017-09-07
Authors
Jiménez Roldán, Luis
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Universidad Complutense de Madrid
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Abstract
Los aneurismas intracraneales son malformaciones vasculares de las arterias cerebrales cuya ruptura supone el vertido de sangre a distintos compartimentos cerebrales, principalmente el espacio subaracnoideo y el intraventricular, dando lugar a la hemorragia subaracnoidea (HSA). Aunque la incidencia de esta enfermedad es menor que la de otras enfermedades cerebrovasculares, la HSA puede ser más devastadora, ya que afecta a una población más joven y presenta unas tasas de mortalidad cercanas al 30% y de morbilidad con mala recuperación funcional cercana al 30%. Los principales factores pronósticos una vez que acontece el sangrado son la edad, la situación clínica inicial y el volumen del sangrado. Estos dos factores están íntimamente relacionados, ya que normalmente cuanto mayor es el volumen de sangre, peor es el grado clínico inicial. Los mecanismos por los que se produce el daño neurológico que conduce a que los pacientes se presenten con peor grado clínico y vayan a tener un peor desenlace permanecen sin aclarar...
Intracranial aneurysms are vascular malformations of the cerebral arteries whose rupture supposes the spill of blood into different cerebral compartments, mainly the subarachnoid space, giving place to the subarachnoid hemorrhage (SAH). Although the incidence of this disease is lower than other cerebrovascular diseases, the SAH may be more devastating, since it affects younger people and presents a mortality rate close to 30% and a morbidity rate with bad functional recovery nearby 30%. The main prognostic factors once the bleeding has happened are age, initial clinical situation and bleeding volume. These two factors are closely related considering that the larger the bleeding volume is, the worst the initial clinical grade is. The mechanisms of the neurological damage that leads to the worst initial clinical grade and to a worst prognosis remain unclear. The initial bleeding spill supposes the turning on of several mechanisms that could influence in those variables...
Intracranial aneurysms are vascular malformations of the cerebral arteries whose rupture supposes the spill of blood into different cerebral compartments, mainly the subarachnoid space, giving place to the subarachnoid hemorrhage (SAH). Although the incidence of this disease is lower than other cerebrovascular diseases, the SAH may be more devastating, since it affects younger people and presents a mortality rate close to 30% and a morbidity rate with bad functional recovery nearby 30%. The main prognostic factors once the bleeding has happened are age, initial clinical situation and bleeding volume. These two factors are closely related considering that the larger the bleeding volume is, the worst the initial clinical grade is. The mechanisms of the neurological damage that leads to the worst initial clinical grade and to a worst prognosis remain unclear. The initial bleeding spill supposes the turning on of several mechanisms that could influence in those variables...
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Tesis inédita de la Universidad Complutense de Madrid, Facultad de Medicina, Departamento de Cirugía, leída el 26-01-2016