Publication: Efectos neurotóxicos del clorpirifos sobre el sistema colinérgico e implicaciones legales del uso del perfil toxicogenómico como biomarcador de toxicidad
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2017-09-08
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Universidad Complutense de Madrid
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Abstract
Clorpirifós (CPF) es uno de los insecticidas organofosforados (OP) más utilizados en aplicaciones agrícolas y residenciales (Figura 1). El CPF es capaz de causar alteraciones de desarrollo, inmunológicas, y efectos neurotóxicos. Por otra parte, la exposición ocupacional a los OP se ha relacionado, en estudios epidemiológicos en humanos, con déficits neurológicos y neuroconductuales, incluyendo alteraciones de la cognición. En este sentido, el CPF se ha demostrado que produce en ratas tras la administración aguda y repetida, déficits de aprendizaje similares a los inducidos en la enfermedad de Alzheimer (AD). Sin embargo, los mecanismos completos a través del cual el CPF induce estas alteraciones cognitivas son desconocidos...
Chlorpyrifos (CPF) is one of the organophosphates (OP) insecticides most widely used in numerous agriculturaland residential settings (Figure 1). CPF is able to cause developmental toxicity, immunological abnormalities, and neurotoxicity. Moreover, OP occupational exposure has been related in human epidemiological studies with neurological and neuro-behavioral deficits including impairments of cognition. In this regard, CPF has been shown to produce learning deficits in rats after acute and repeated administration similar to those induced in Alzheimer’s disease (AD). However, the complete mechanisms through which CPF induces these cognitive alterations are unknown...
Chlorpyrifos (CPF) is one of the organophosphates (OP) insecticides most widely used in numerous agriculturaland residential settings (Figure 1). CPF is able to cause developmental toxicity, immunological abnormalities, and neurotoxicity. Moreover, OP occupational exposure has been related in human epidemiological studies with neurological and neuro-behavioral deficits including impairments of cognition. In this regard, CPF has been shown to produce learning deficits in rats after acute and repeated administration similar to those induced in Alzheimer’s disease (AD). However, the complete mechanisms through which CPF induces these cognitive alterations are unknown...
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Tesis inédita de la Universidad Complutense de Madrid, Facultad de Medicina, Departamento de Toxicología y Legislación Sanitaria, leída el 30-06-2016