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Pulmonary surfactant metabolism in the alveolar airspace: Biogenesis,extracellular conversions, recycling

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Olmeda Lozano, Bárbara and Martínez Calle, Marta and Pérez Gil, Jesús (2017) Pulmonary surfactant metabolism in the alveolar airspace: Biogenesis,extracellular conversions, recycling. Annals of Anatomy, 209 . pp. 78-92. ISSN 0940-9602, ESSN: 1618-0402

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Official URL: http://www.sciencedirect.com/science/article/pii/S094096021630173X



Abstract

Pulmonary surfactant is a lipid–protein complex that lines and stabilizes the respiratory interface in the alveoli, allowing for gas exchange during the breathing cycle. At the same time, surfactant constitutes the first line of lung defense against pathogens. This review presents an updated view on the processes involved in biogenesis and intracellular processing of newly synthesized and recycled surfactant components, as well as on the extracellular surfactant transformations before and after the formation ofthe surface active film atthe air–water interface. Special attention is paid to the crucial regulation of surfactant homeostasis, because its disruption is associated with several lung pathologies.


Item Type:Article
Uncontrolled Keywords:Pulmonary surfactant; Lung; Surface tension; Air–liquid interface; Pneumocyte
Subjects:Medical sciences > Biology > Biochemistry
ID Code:44601
Deposited On:13 Sep 2017 08:25
Last Modified:13 Sep 2017 08:31

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