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Mimicking Peroxidase Activities with Prussian Blue Nanoparticles and Their Cyanometalate Structural Analogues

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Vázquez González, Margarita and Torrente Rodríguez, Rebeca M. and Kozell, Anna and Liao, Wei-Ching and Cecconello, Alessandro and Campuzano, Susana and Pingarrón, José M. and Willner, Itamar (2017) Mimicking Peroxidase Activities with Prussian Blue Nanoparticles and Their Cyanometalate Structural Analogues. Nano Letters, 17 (8). pp. 4958-4963. ISSN (Print)1530-6984 (On line)1530-6992

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Official URL: http://pubs.acs.org/doi/abs/10.1021%2Facs.nanolett.7b02102



Abstract

Nanoparticles composed of Prussian Blue, PB, and the cyanometalate structural analogues, CuFe, FeCoFe, and FeCo, are examined as inorganic clusters that mimic the functions of peroxidases. PB acts as a superior catalyst for the oxidation of dopamine to aminochrome by H2O2. The oxidation of dopamine by H2O2 in the presence of PB is 6-fold faster than in the presence of CuFe. The cluster FeCo does not catalyze the oxidation of dopamine to aminochrome. The most efficient catalyst for the generation of chemiluminescence by the oxidation of luminol by H2O2 is, however, FeCo, and PB lacks any catalytic activity toward the generation of chemiluminescence. The order of catalyzed chemiluminescence generation is FeCo ≫ CuFe > FeCoFe. The clusters PB, CuFe, FeCoFe, and FeCo mimic the functions of NADH peroxidase. The catalyzed oxidation of NADH by H2O2 to form NAD+ follows the order PB ≫ CuFe ∼ FeCoFe, FeCo. The efficient generation of chemiluminescence by the FeCo-catalyzed oxidation of luminol by H2O2 is used to develop a glucose sensor. The aerobic oxidation of glucose in the presence of glucose oxidase, GOx, yields gluconic acid and H2O2. The chemiluminescence intensities formed by the GOx-generated H2O2 relate to the concentration of glucose, thus providing a quantitative readout signal for the concentrations of glucose.


Item Type:Article
Uncontrolled Keywords:NADH, chemiluminescence, dopamine, sensor, catalysis
Subjects:Sciences > Chemistry > Analytic chemistry
ID Code:44690
Deposited On:18 Sep 2017 09:53
Last Modified:18 Sep 2017 10:46

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