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A versatile fluorescent molecular probe endowed with singlet oxygen generation under white-light photosensitization

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Durán Sampedro, Gonzalo and Epelde Elezcano, Nerea and Martínez Martínez, Virginia and Esnal Martínez, Ixone and Bañuelos Prieto, Jorge and García Moreno, Inmaculada and Rodríguez Agarrabeitia, Antonia and Moya Cerero, Santiago de la and Tabero Truchado, Andrea and Lázaro Carrillo, Ana and Villanueva Oroquieta, Ángeles and Ortíz García, María Josefa and López Arbeloa, Íñigo María (2017) A versatile fluorescent molecular probe endowed with singlet oxygen generation under white-light photosensitization. Dyes and Pigments, 142 . pp. 77-87. ISSN 0143-7208

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Official URL: http://dx.doi.org/10.1016/j.dyepig.2017.03.026



Abstract

Despite fluorescent photodynamic therapy (fluorescent-PDT) dyes are promising theranostic agents, current approaches unfortunately involve crucial shortcomings (such as, narrow absorption bands, high cost, low bio-compatibility and specificity, low dual efficiency) making difficult their clinical translation. Particularly, efficient fluorescent-PDT agents triggered under white-light, with potential application in topic solar treatments, are scarce. Here, we describe the rational development of a novel fluorescent-PDT molecular biomaterial based on BODIPY building blocks able to sustain, simultaneously, synthetic accessibility, high fluorescence and phototoxicity within a broad spectral window, biocompatibility, including low dark toxicity and high cell permeability with selective accumulation in lysosomes and, what is more important, excellent efficient activity triggered under white light. These all-in-one combined properties make the new dye a valuable ground platform for the development of future smarter theranostic agents.


Item Type:Article
Additional Information:

Received 30 January 2017, Revised 10 March 2017, Accepted 11 March 2017, Available online 12 March 2017.

Uncontrolled Keywords:BODIPY dyes; Photosensitizers; Singlet oxygen; Theragnosis; White light; Photodynamic therapy
Subjects:Sciences > Chemistry > Physics
Sciences > Chemistry > Materials
Sciences > Chemistry > Chemistry, Organic
Medical sciences > Biology > Biochemistry
ID Code:45025
Deposited On:06 Oct 2017 07:36
Last Modified:09 Oct 2017 07:47

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