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Ultrasound-triggered local anaesthesia

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Rwei, Alina Y. and Paris, J.L. and Wang, Bruce and Axon, Christopher D. and Vallet Regí, María and Langer, Robert and Kohane, Daniel S. and Weiping, Wang (2017) Ultrasound-triggered local anaesthesia. Nature Biomedical Engineering, 1 . pp. 644-653. ISSN 2157-846X

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Official URL: http://www.nature.com/natbiomedeng/



Abstract

On-demand relief of local pain would allow patients to control the timing, intensity and duration of nerve blocks in a safe and non-invasive manner. Ultrasound would be a suitable trigger for such a system, as it is in common clinical use and can penetrate deeply into the body. Here, we demonstrate that ultrasound-triggered delivery of an anaesthetic from liposomes allows the timing, intensity and duration of nerve blocks to be controlled by ultrasound parameters. On insonation, the encapsulated sonosensitizer protoporphyrin IX produced reactive oxygen species that reacted with the liposomal membrane, leading to the release of the potent local anaesthetic tetrodotoxin. Repeatable ultrasound-triggered nerve blocks were achieved in vivo, with the nerve-block duration depending on the extent and intensity of insonation. There was no detectable systemic toxicity and tissue reaction was benign in all groups. On-demand, personalized local anaesthesia could be beneficial for the management of relatively localized pain states and could potentially minimize opioid use.


Item Type:Article
Subjects:Sciences > Chemistry > Materials
Sciences > Chemistry > Chemistry, Inorganic
ID Code:45107
Deposited On:10 Nov 2017 13:10
Last Modified:10 Feb 2018 00:01

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