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A novel visible light responsive nanosystem for cancer treatment

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Martínez Carmona, Marina and Lozano Borregón, Daniel and Baeza, Alejandro and Colilla, Montserrat and Vallet Regí, María (2017) A novel visible light responsive nanosystem for cancer treatment. Nanoscale (9). pp. 15967-15973. ISSN 2040-3372

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Abstract

A novel singlet-oxygen sensitive drug delivery nanocarrier able to release their cargo after exposure to visible (Vis) light of a common lamp is presented. This nanodevice is based on mesoporous silica nanoparticles (MSN) decorated with porphyrin-caps grafted via reactive oxygen species (ROS)-cleavable linkages. In presence of Vis light the porphyrinnanocaps produce singlet oxygen molecules that break the sensitive-linker, which triggers pore uncapping and therefore allows the release of the entrapped cargo (topotecan, TOP). This new system takes advantage of thE non-toxicity and greater penetration capacity of Vis radiation and a double antitumor effect due to the drug release and the ROS production. In vitro tests with HOS osteosarcoma cancer cells reveal that TOP is able to be released in a controlled fashion inside the tumor cells. This research work constitutes a proof of concept that opens up promising expectations in the seeking for new alternatives for the treatment of cancer.


Item Type:Article
Uncontrolled Keywords:Cancer treatment, Mesoporous silica nanoparticles (MSN), Singlet oxygen molecules
Subjects:Sciences > Chemistry > Materials
Sciences > Chemistry > Chemistry, Inorganic
ID Code:45134
Deposited On:03 Nov 2017 12:42
Last Modified:20 Sep 2018 23:01

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