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Epigenetics in the Eye: An Overview of the Most Relevant Ocular Diseases

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Alkozi, Hanan Awad and Franco, Rafael and Pintor, Jesús (2017) Epigenetics in the Eye: An Overview of the Most Relevant Ocular Diseases. Frontiers in Genetics, 8 . art. 144. ISSN 1663-4365

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Official URL: https://doi.org/10.3389/fgene.2017.00144




Abstract

Sight for mammals is one of the most appreciated senses. In humans there are several factors that contribute to the increment in all kind of eye diseases. This mini-review will focus on some diseases whose prevalence is steadily increasing year after year for non-genetic reasons, namely cataracts, dry eye, and glaucoma. Aging, diet, inflammation, drugs, oxidative stress, seasonal and circadian style-of-live changes are impacting on disease prevalence by epigenetics factors, defined as stable heritable traits that are not explained by changes in DNA sequence. The mini-review will concisely show the data showing epigenetics marks in these diseases and on how knowledge on the epigenetic alterations may guide therapeutic approaches to have a healthy eye.


Item Type:Article
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This Document is Protected by copyright and was first published by Frontiers. All rights reserved. it is reproduced with permission.

Uncontrolled Keywords:Cataracts, Glaucoma, Dry eye, Keratoconus, Eye diseases
Subjects:Medical sciences > Medicine > Ophtalmology
ID Code:45565
Deposited On:27 Nov 2017 12:13
Last Modified:11 Dec 2017 12:57

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