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Mechanisms of immune regulation in allergic diseases: the role of regulatory T and B cells

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Palomares Gracia, Oscar y Akdis, Mübeccel y Martín Fontecha, María del Mar y Akdis, Cezmi A. (2017) Mechanisms of immune regulation in allergic diseases: the role of regulatory T and B cells. Immunological Reviews, 278 (1). pp. 219-236. ISSN 0105-2896

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URL Oficial: https://doi.org/10.1111/imr.12555




Resumen

Allergy is a major public health problem with a high socio-economic impact. The number of allergic patients is expected to reach to four billion within two decades when the World's population reaches to 10 billion. Our knowledge on the molecular mechanisms underlying allergic diseases and allergen tolerance induction had significant advances during the last years. Nowadays, it is well accepted that the generation and maintenance of allergen-specific regulatory T cells (Tregs) and regulatory B cells (Bregs) and the involvement of their suppressive cytokines and surface molecules are essential for the induction of allergen tolerance. These mechanisms play essential roles for the restoration of healthy immune responses to allergens in allergen-specific immunotherapy (AIT) and healthy immune response during high-dose antigen exposure in beekeepers and cat owners. AIT remains as the only disease-modifying and curative treatment for allergic diseases and represents a perfect model to investigate the antigen-specific immune responses in humans. A large number of clinical trials demonstrated AIT as an effective treatment in many patients, but it still faces several drawbacks in relation to efficacy, safety, long duration, and patient adherence. Novel strategies to overcome these inconveniences, such as the development of novel adjuvants and alternative routes of administration are being developed. The better understanding of the molecular mechanism governing the generation of Treg and Breg cells during allergen tolerance might well open new avenues for alternative therapeutic interventions in allergic diseases and help better understanding of other immune-tolerance-related diseases.


Tipo de documento:Artículo
Información Adicional:

Special issue: Allergic Inflammation

Palabras clave:Breg cells; Treg cells; Allergen tolerance; Allergen-specific immunotherapy; Allergy; immunologic mechanisms
Materias:Ciencias Biomédicas > Medicina > Fisiología
Ciencias Biomédicas > Medicina > Inmunología
Ciencias Biomédicas > Biología > Biología celular
Código ID:45640
Depositado:11 Dic 2017 13:39
Última Modificación:11 Dic 2017 16:09

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