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Mesoporous Silica Nanoparticles for Drug Delivery: Current Insights

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Vallet Regí, María and Colilla, Montserrat and Izquierdo-Barba, Isabel and Manzano García, Miguel (2017) Mesoporous Silica Nanoparticles for Drug Delivery: Current Insights. MOLECULES, 23 (1). p. 47. ISSN 10.3390/molecules23010047

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Official URL: http://www.mdpi.com/journal/molecules




Abstract

This manuscript reviews the recent progress on mesoporous silica nanoparticles as drug delivery systems. Their intrinsic structural, textural and chemical features permit to design versatile multifunctional nanosystems with the capability to target the diseased tissue and release the cargo on demand upon exposition to internal or external stimuli. The degradation rate of these nanocarriers in diverse physiological fluids is overviewed obeying their significance for their potential translation towards clinical applications. To conclude, the balance between the benefits and downsides of this revolutionary nanotechnological tool is also discussed.


Item Type:Article
Additional Information:

RESEARCHER ID M-3378-2014 (María Vallet Regí)
ORCID 0000-0002-6104-4889 (María Vallet Regí)
RESEARCHER ID N-4628-2014 (Montse Colilla Nieto)
RESEARCHER ID M-9921-2014 (Isabel Izquierdo Barba)
ORCID 0000-0002-4139-4646 (Isabel Izquierdo Barba)
ORCID 0000-0003-1961-4160 (Montse Colilla Nieto)
RESEARCHER ID K-3719-2014 (Miguel Manzano García)
ORCID 0000-0001-6238-6111 (Miguel Manzano García)

Uncontrolled Keywords:mesoporous silica nanoparticles; multifunctional nanosystem; selective targeting; stimuliresponsive drug delivery; in vitro degradation; benefits and downsides; clinical translation; biosafety
Subjects:Sciences > Chemistry > Materials
Sciences > Chemistry > Chemistry, Inorganic
ID Code:45935
Deposited On:02 Feb 2018 13:25
Last Modified:05 Feb 2018 08:42

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