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Self-immolative chemistry in nanomedicine

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Gisbert Garzarán, Miguel and Manzano García, Miguel and Vallet Regí, María (2017) Self-immolative chemistry in nanomedicine. Chemical Engineering Journal . ISSN 1385-8947

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Official URL: http://www.sciencedirect.com/science/article/pii/S1385894717322209




Abstract

Self-immolative chemistry is based on the cascade of disassembling reactions triggered by the adequate stimulation and leading to the sequential release of the smaller constituent elements. This review will focus on the possibilities that this type of chemistry offers to nanomedicine research, which is an area where the stimuli responsive behavior is always targeted. There are some examples on the use of self-immolative chemistry for prodrugs or nanoparticles for drug delivery, but there is still an exciting land of opportunities waiting to be explored. This review aims at revising what has been done so far, but, most importantly, it aims at inspiring new research of self-immolative chemistry on nanomedicine.


Item Type:Article
Additional Information:

RESEARCHER ID S-2443-2016 (Miguel Gisbert Garzarán)
ORCID 0000-0001-9815-0354 (Miguel Gisbert Garzarán)
RESEARCHER ID K-3719-2014 (Miguel Manzano García)
ORCID 0000-0001-6238-6111 (Miguel Manzano García)
RESEARCHER ID M-3378-2014 (María Vallet Regí)
ORCID 0000-0002-6104-4889 (María Vallet Regí)

Uncontrolled Keywords:Self-immolative, Nanomedicine Mesoporous silica nanoparticles, Polymer nanoparticles, Prodrugs
Subjects:Sciences > Chemistry > Materials
Medical sciences > Pharmacy > Inorganic chemistry
ID Code:45942
Deposited On:13 Feb 2018 09:09
Last Modified:24 Dec 2019 00:01

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